Figure 5

Functional connectivity of the STG-IFG network is associated with multivariate symptom patterns.

Panels (A)–(F) correspond to the six inter-regional connections shown in Fig. 3C. The horizontal axis of each panel represents positive scores from PANSS and the vertical axis indicates negative scores. The black squares mark EOS n > p patients and the gray circles EOS p > n. The colors represent the difference in functional connectivity strength relative to TDC (predicted by the models), where 100% indicates the connectivity strength is the same as the mean strength of TDC subjects. The predictions were obtained from linear models including positive scores, negative scores, the interaction between the two scores and head motion parameters as regressors. The interaction between positive and negative scores exhibits a significant effect on functional connectivity strength in (E), as reflected by the changes of functional connectivity strength along the diagonal. The same trend is also shown in (C) and (D), although the interaction effect is not statistically significant.