Table 1 Genotype distribution and allele frequencies of IL-6 gene polymorphisms in RA patients and control individuals

From: Association between Interleukin-6 Gene Polymorphisms and Rheumatoid Arthritis in Chinese Han Population: A Case-Control Study and A Meta-analysis

 

Genotypes/

RA

Controls

P

Odds

95%confidence

SNPs

Alleles

(n = 256)

(n = 331)

value

ratio

interval

rs1800795

GG

247(96.5%)

329(99.4%)

0.049

3.235

1.005–10.412

 

GC

7(2.7%)

1(0.3%)

   
 

CC

2(0.8%)

1(0.3%)

   
 

G

501(97.9%)

659(99.5%)

0.016

4.823

1.338–17.379

 

C

11(2.1%)

3(0.5%)

   

rs1800796

CC

108(42.2%)

138(41.7%)

0.476

1.095

0.854–1.404

 

CG

125(48.8%)

152(45.9%)

   
 

GG

23(9.0%)

41(12.4%)

   
 

C

341(66.6%)

428(64.7%)

0.486

1.090

0.855–1.390

 

G

171(33.4%)

234(35.3%)

   

rs1800797

GG

249(97.3%)

330(99.7%)

0.076

3.419

0.879–13.305

 

GA

5(1.9%)

0(0%)

   
 

AA

2(0.8%)

1(0.3%)

   
 

G

503(98.2%)

660(99.7%)

0.024

5.905

1.270–27.448

 

A

9(1.8%)

2(0.3%)

   

rs1524107

TT

99(38.7%)

143(43.2%)

0.376

1.116

0.875–1.422

 

TC

125(48.8%)

148(44.7%)

   
 

CC

32(12.5%)

40(12.1%)

   
 

T

323(63.1%)

434(65.6%)

0.380

1.114

0.876–1.417

 

C

189(36.9%)

228(34.4%)

   

rs2069840

CC

199(77.7%)

278(84.0%)

0.057

1.435

0.990–2.081

 

CG

52(20.3%)

49(14.8%)

   
 

GG

5(2.0%)

4(1.2%)

   
 

C

450(87.9%)

605(91.4%)

0.050

1.462

1.000–2.138

 

G

62(12.1%)

57(8.6%)

   

rs1474347

TT

243(94.9%)

326(98.5%)

0.019

3.488

1.227–9.915

 

TG

13(5.1%)

5(1.5%)

   
 

GG

0(0%)

0(0%)

   
 

T

499(97.5%)

657(99.2%)

0.020

3.423

1.212–9.665

 

G

13(2.5%)

5(0.8%)

   
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