Figure 2
From: Developing Hypothetical Inhibition Mechanism of Novel Urea Transporter B Inhibitor
One extracellular (binding site 1) and two intracellular (binding site 2 and 3) hypothetic binding sites are predicted.
Key residues that are predicted to interact with UT-B inhibitors are shown. Pocket residues are shown in white while the distance between residue and ligand was set to 2.5Å. Cross-species and mutation studies suggest binding site 1 might be a possible pocket for UT-B inhibitor binding (see below).
