Figure 5
From: Developing Hypothetical Inhibition Mechanism of Novel Urea Transporter B Inhibitor
Figure illustrates the structural differences in inhibitor binding site in UT-B between human, mouse and rat.
Re-docking poses of PU21, PU168, PU468 and PU474 in human are shown at (a–d), respectively. PU21 and PU468 re-docking poses in mouse and rat UT-B are shown at (e–f) and (g–h), respectively. The tertiary structure of the extracellular binding site demonstrates the steric hindrance difference, which is caused by PHE198 in mouse or rat UT-B. Only PU21 and PU468 can anchor in human, mouse and rat UT-B.
