Table 1 Lysine 898 is an evolutionarily conserved residue in BRCA1

From: The K898E germline variant in the PP1-binding motif of BRCA1 causes defects in DNA Repair

Species

Accession Number

Starting Residue No.

Sequence

Ending Residue No.

Human

P38398

893

KKQSPKVTFECEQKEE

908

Gorilla

Q6J6I8

893

KKQSPKVTFECEQKEE

908

Orangutan

Q6J6J0

893

KKQSPKVTFECEQKEE

908

Chimpanzee

Q9GKK8

893

KKQSPKVTFEREQKEQ

908

Macaque

Q6J6I9

892

KKQSPKVTSECEQKEE

907

Mouse

P48754

879

KELSPKVTAKGKQKER

894

Rat

O54952

883

REPSPKVTSRGEQKER

898

Pig

A5A751

884

REQSPKVTHEGGQKDE

899

Horse

F6SQ43

894

RKRSPKVTLKCGQKEG

909

Dog

Q95153

891

GKQGPKVTLECGQKEE

906

  1. UniProtKB accession numbers for each BRCA1 homolog are provided. The starting and ending residue numbers refer to the positions of the first and last amino acids shown in the sequence. The putative PP1-binding motif is highlighted in bold.
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