Figure 1 | Scientific Reports

Figure 1

From: Long noncoding RNA associated-competing endogenous RNAs in gastric cancer

Figure 1

Competing endogenous RNAs (ceRNAs) function as microRNA (miRNA) sponges sequester miRNAs to regulate expression level of other transcripts sharing common miRNA response elements (MREs).

(A) Downregulation of long noncoding RNAs (lncRNA) leads more miRNA molecules free to bind to mRNA that contain the same MREs, thus its protein expression level decreases. (B) Overexpression of lncRNA leads fewer miRNA molecules to bind to mRNA, thus its protein expression level increases.

Back to article page