Figure 5
From: NEK9-dependent proliferation of cancer cells lacking functional p53
Expression of NEK9 protein in lung cancer.
(A) Representative images of NEK9 and p53 double-positive lung adenocarcinoma (ADC, upper left pair of images), squamous cell carcinoma (SQC, upper right pair), large cell neuroendocrine carcinoma (LCNEC, bottom left pair) and small cell lung carcinoma (SCLC, bottom right pair). The tables below each image pair show the number of samples of each type of cancer that contained positively stained cells. (B) NEK9- and p53-positive cases of ADC and SQC, with histological differentiation type indicated for each case. (C) Kaplan–Meier survival curves comparing NEK9 and p53 double-positive ADCs versus other types of ADCs. Vertical axis indicates overall survival (OS); horizontal axis indicates duration (months). Statistical analysis was carried out by Wilcoxon test. (D) Levels of NEK9 mRNA in human lung ADCs were determined by microarray analysis. TP53 mutation status was determined by whole-exome sequencing. Boxes represent the upper and lower quartiles and the median and whiskers show the maximum and minimum values.
