Figure 5 | Scientific Reports

Figure 5

From: Microneedle-mediated immunization of an adenovirus-based malaria vaccine enhances antigen-specific antibody immunity and reduces anti-vector responses compared to the intradermal route

Figure 5

Antigen expression levels by HAdV5 when delivered by ID or MN route.

(A) In vivo imaging of luciferase expression following delivery of HAdV5 expressing luciferase to BALB/c mice by the ID (n = 3, left panels) or microneedle array type D (n = 4, right panels). Photon emissions in each group are shown at day 2 or day 10 (5 minute exposure); the emissions were measured using an RLU scale. (B) Total flux (as defined by photons emitted per second) was assessed by injection of D-luciferin at day 2, 7, 10 and 14 in each animal and is graphed on a log scale.

Back to article page