Table 1 Inhibition constants of Q1 for HsHex and OfHex1

From: A crystal structure-guided rational design switching non-carbohydrate inhibitors' specificity between two β-GlcNAcase homologs

Inhibitor

HsHex

OfHex1

OfHex1 (W490A)

M31850

3.22a (0.80b)

NI

NI

a1

2.08

NI

NI

7a

0.63a

NI

NI

Q1

2.15

4.28

NI

Q2

NI

0.31

NI

  1. Ki values are presented in µM. NI, not inhibited at 100 µM. aData from Ref. 36. bData from Ref. 35.
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