Table 3 Multivariable logistic regression coefficients and odds ratios for the NTCP models for patient-reported xerostomia 3 and 12 months after treatment

From: LASSO NTCP predictors for the incidence of xerostomia in patients with head and neck squamous cell carcinoma and nasopharyngeal carcinoma

 

Predictive factors

β

p

Odds Ratio

95% CI

XER HNSCC-3m

(n = 3)

    
 

Dmean-c

0.637

<0.001

1.892

1.724–2.075

 

Dmean-i

0.185

<0.001

1.203

1.164–1.243

 

Age

0.202

<0.001

1.223

1.159–1.291

 

Constant

−32.296

<0.001

  

XER HNSCC-12m

(n = 3)

    
 

Dmean-c

1.400

<0.001

4.054

3.287–5

 

Dmean-i

0.358

<0.001

1.43

1.33–1.539

 

T stage

    
 

T0

0.622

0.182

1.862

0.747–4.64

 

T1

−1.136

<0.001

0.321

0.184–0.562

 

T2

−19.544

0.99

0

0

 

T3

0

<0.001

0

 
 

Constant

−44.877

<0.001

  

XER NPC-3m

(n = 4 )

    
 

Dmean-c

0.218

<0.001

1.244

1.195–1.295

 

Dmean-i

0.185

<0.001

1.203

1.157–1.251

 

Financial status

    
 

f0

21.754

0.028

2.889

 
 

f1

21.316

0.998

1.889

 
 

f2

42.23

0.998

2.218

 
 

f3

0

0.997

  
 

Age

0.158

0

1.171

1.124–1.22

 

Constant

−44.98

<0.001

  

XER NPC-12m

(n = 3)

    
 

Dmean-c

0.558

<0.001

1.747

1.613–1.893

 

Dmean-i

0.538

<0.001

1.712

1.585–1.85

 

Education

    
 

E0

0

<0.001

0

 
 

E1

1.228

0.009

3.413

1.367–8.526

 

E2

2.198

<0.001

9.011

3.543–22.919

 

Constant

−45.962

<0.001

0

 
  1. Abbreviation: Dmean-c: the mean dose given to the contralateral parotid gland; Dmean-i: the mean dose given to the ipsilateral parotid gland; SIB: simultaneous integrated boost; SQM: sequential mode; HNSCC: head and neck squamous cell carcinoma; NPC: nasopharyngeal carcinoma; LASSO: least absolute shrinkage and selection operator; XER: Xerostomia; XER3m or 12m: patient-reported moderate- to-severe xerostomia after 3- or 12-month.
Back to article page