Table 6 Parameter estimates from the univariate logistic regression NTCP model

From: LASSO NTCP predictors for the incidence of xerostomia in patients with head and neck squamous cell carcinoma and nasopharyngeal carcinoma

 

HNSCC

NPC

Month

Parameter

TD50 (CI95%)

γ (CI95%)

TD50 (CI95%)

γ (CI95%)

3m

Dmean-c

24.3 (24.0–24.5)

8.30 (7.25–9.44)

36.0 (34.3–37.8)

1.69 (1.64–1.71)

 

Dmean-i

35.3 (33.3–37.4)

1.80 (1.80–1.83)

38.3 (36.1–40.7)

1.39 (1.33–1.44)

12m

Dmean-c

25.4 (24.5–26.3)

2.41 (2.20–2.54)

40.0 (39.1–40.9)

3.96 (3.56–3.99)

 

Dmean-i

38.0 (34.9–41.2)

1.17 (1.17–1.21)

42.8 (41.9–43.7)

4.35 (3.92–4.30)

  1. Abbreviation: NTCP: Normal tissue complication probability; HNSCC: head and neck squamous cell carcinoma; NPC: nasopharyngeal carcinoma; TD50: the gland tolerance dose (Gy) that would result in a 50% risk of normal tissue complications for patient-reported moderate- to-severe xerostomia within a specific period of time; γ: the slope of the response curve. Dmean-c: mean dose to the contralateral parotid glands; Dmean-i: mean dose to the ipsilateral parotid glands.
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