Table 3 False-Positive Report Probability Values for associations between ESCC risk and genotypes of ERCC2 polymorphisms

From: Potentially functional polymorphisms in the ERCC2 gene and risk of Esophageal Squamous Cell Carcinoma in Chinese populations

    

     Prior probability

Genotypes

Positive OR (95% CI) a

P value b

Statistical Power c

0.2500

0.1000

0.0100

0.0010

0.0001

rs238406

        

TT vs. GG

1.24 (0.98–1.57)

0.075

0.988

0.185

0.406

0.883

0.987

0.999

TG/TT vs. GG

1.24 (1.04–1.49)

0.017

0.975

0.050

0.136

0.633

0.946

0.994

Pack-years > 16

1.49 (1.12–1.98)

0.006

0.523

0.033

0.094

0.532

0.920

0.991

Combined risk genotypes

        

No. at-risk genotypes d

        

1 vs. 0

1.25 (1.03–1.52)

0.026

0.984

0.073

0.192

0.723

0.964

0.996

2 vs. 0

1.62 (1.16–2.26)

0.005

0.452

0.032

0.091

0.523

0.917

0.991

≥1 vs. 0

1.28 (1.06–1.56)

0.011

0.930

0.034

0.096

0.539

0.922

0.992

  1. aThe crude OR reported in Tables 2 and 3.
  2. bThe omnibus chi-square test of the genotype frequency distributions reported in Tables 2 and 3.
  3. cStatistical power was calculated using the number of observations in the study and the OR and P values in Tables 2 and 3.
  4. dCombined risk genotypes were to referred to ERCC2 rs238406 TG/TT + rs13181 TG/GG.
Back to article page