Table 4 Meta-analysis of the association between ERCC2 rs13181 polymorphism and esophageal cancer risk
No. of studies | GG vs. TT | TG vs. TT | GG vs. TG/TT | TG/GG vs. TT | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Variables | OR (95% CI)c | P OR a | P het b | OR (95% CI)d | P OR a | P het b | OR (95% CI)c | P OR a | P het b | OR (95% CI)d | P OR a | P het b | |
All | 19 | 1.28 (1.08–1.52) | 0.005 | 0.075 | 1.15 (1.01–1.30) | 0.030 | 0.025 | 1.19 (1.01–1.40) | 0.034 | 0.231 | 1.17 (1.02–1.33) | 0.020 | 0.004 |
Ethnicity | |||||||||||||
Asian | 11 | 1.36 (0.97–1.91) | 0.078 | 0.165 | 1.16 (1.00–1.35) | 0.050 | 0.141 | 1.28 (0.92–1.80) | 0.140 | 0.176 | 1.18 (1.01–1.39) | 0.115 | 0.052 |
Non-Asian | 8 | 1.26 (1.03–1.54) | 0.025 | 0.071 | 1.14 (0.90–1.43) | 0.276 | 0.019 | 1.16 (0.97–1.40) | 0.110 | 0.331 | 1.14 (0.90–1.45) | 0.267 | 0.007 |
Histological type | |||||||||||||
Squamous Cell | 12 | 1.33 (0.98–1.79) | 0.064 | 0.152 | 1.17 (1.01–1.37) | 0.039 | 0.083 | 1.20 (0.90–1.60) | 0.216 | 0.200 | 1.19 (1.01–1.40) | 0.034 | 0.028 |
Adenocarcinoma | 6 | 1.26 (1.02–1.55) | 0.036 | 0.048 | 1.09 (0.85–1.41) | 0.500 | 0.023 | 1.18 (0.97–1.44) | 0.095 | 0.215 | 1.11 (0.85–1.44) | 0.448 | 0.008 |
Other | 1 | 3.13 (0.13–77.85) | 0.486 | 0.076 | 1.33 (0.57–3.08) | 0.507 | -- | 3.03 (0.12–75.19) | 0.499 | -- | 1.42 (0.62–3.26) | 0.404 | -- |
Publication Bias e | 0.955 | 0.414 | 0.970 | 0.497 | |||||||||
