Table 2 Genotype and minor allele frequencies of 9 SNPs in 6 genes in controls, DSPT and FRT individuals

				Control (N = 925)			DSPT (N = 182)			FRT (N = 67)			Control	DSPT		FRT
Gene	SNP	Allele (A/a)	Variation (amino acid)	AA	Aa	aa	AA	Aa	aa	AA	Aa	aa	MAF	MAF	permutated P (χ2)	MAF	permutated P (χ2)
CLOCK	rs1801260	T/C		0.707	0.268	0.025	0.665	0.297	0.038	0.687	0.284	0.03	0.159	0.187	0.218	0.172	0.715
NPAS2	rs2305160	G/A	A/T	0.659	0.297	0.043	0.698	0.264	0.038	0.612	0.343	0.045	0.192	0.17	0.355	0.216	0.502
PER1	rs2585405	C/G	P/A	0.345	0.477	0.178	0.335	0.538	0.126	0.403	0.418	0.179	0.417	0.396	0.489	0.388	0.535
PER2	rs2304672	C/G		0.893	0.106	0.001	0.918	0.077	0.005	0.866	0.119	0.015	0.054	0.044	0.666	0.075	0.539
	rs934945	G/A	G/E	0.476	0.428	0.096	0.516	0.401	0.082	0.448	0.507	0.045	0.31	0.283	0.518	0.299	0.950
PER3	rs228697	C/G	P/A	0.846	0.149	0.004	0.846	0.143	0.011	0.716	0.284	0	0.079	0.082	0.941	0.142	0.017*
	rs2640909	T/C	M/T	0.782	0.204	0.014	0.775	0.198	0.027	0.657	0.343	0	0.116	0.126	0.765	0.172	0.088
TIM	rs774047	A/G	Q/R	0.354	0.456	0.19	0.407	0.467	0.126	0.284	0.522	0.194	0.418	0.36	0.058	0.455	0.527
	rs2291739	C/T	P/L	0.316	0.474	0.211	0.363	0.489	0.148	0.313	0.478	0.209	0.448	0.393	0.082	0.448	1

A, major allele; a, minor allele; N, number; MAF, minor allele frequency; P, P value for the difference in MAF between DSPT or FRT patients and controls;
*, P < 0.05.

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