Figure 3
From: Changes of the human gut microbiome induced by a fermented milk product
Metabolic reconstruction of unknown gut microbial species shows a FMP-mediated increase of potential butyrate producers.
A) Projection on KEGG metabolic pathways of functions encoded by the MGS126 reconstructed genome (in red) using Ipath tool55. Functions of the KEGG global map were depicted underneath. B) Presence of genes predicted to encode enzymes of the butyrate synthesis pathway (thiolase EC 2.3.1.9 (THL); β-hydroxybutyryl-CoA dehydrogenase (BHCD; EC 1.1.1.35); crotonase (CRO; EC 4.2.1.17); butyryl-CoA dehydrogenase (BCD; EC 1.3.99.2); Electron-Transfer Flavoprotein α and β sub-units (ETFα and ETF β; E.C. 1.5.5.1); butyrate kinase (BK; EC 2.7.2.7); butyryl-coA acetyl-coA transferase (ButCoA; EC 2.8.3.8) among the reconstituted Clostridiales MGS. C) Abundance of butyrogenic modules of the human gut microbiota in the IBS cohort at baseline. Mean and standard deviation are represented. Results are presented using Tukey box-and-whisker plots.
