Figure 7 | Scientific Reports

Figure 7

From: Characterizing the pocketome of Mycobacterium tuberculosis and application in rationalizing polypharmacological target selection

Figure 7

A selected example of similar binding sites in different proteins predicted in this study matching with crystal structures available in literature (A) Structural superposition of dihydrofolate reductase (red cartoon) and InhA (blue cartoon, PDBID: 1ZID) protein based on the similarity of the binding sites (shown as sticks). The inset shows the similarity of the binding sites with the isoniazid adduct shown in ball and stick representation. (B) Crystal structure of dihydrofolate reductase with characterization of binding site for isoniazid adduct (PDBID: 2CIG).

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