Figure 5
Effects of dietary enrichment with 5% eicosapentaenoic acid on renal function, urinalysis and MPO-ANCA titers in SCG/Kj mice.
(A) Grade of hematuria (left) and proteinuria (right) in SCG/Kj mice fed a control or a 5% eicosapentaenoic acid (EPA)-containing diet. EPA supplementation significantly relieved hematuria, but not proteinuria. (B) Serum creatinine (left) and blood urea nitrogen (right) in SCG/Kj mice fed a control (n = 11) or a 5% EPA-containing (n = 11) diet. EPA supplementation prevented impairment of renal function. (C) MPO-ANCA titers in SCG/Kj mice fed a control diet or a 5% EPA-containing diet (left) and a 5% corn oil or a 5% EPA-containing diet (right). EPA supplementation strongly blocked production of MPO-ANCA. Each bold bar indicates a median value. Statistical differences were evaluated using Student's t-test. (*p < 0.05 compared with control).
