Figure 4 | Scientific Reports

Figure 4

From: Quantitative High-Throughput Profiling of Environmental Chemicals and Drugs that Modulate Farnesoid X Receptor

Figure 4

Distribution of biological functions of selective potent FXR-actives.

Thirty-five FXR-active drugs with submicromolar potency and known biological targets were chosen to form clusters based on biological functions. (a) Distribution of drug classes. (b) Distribution of target classes. (c) Concentration-dependent inhibition curves of nocodazole (IC50 = 320 nM), colchicine (IC50 = 11 nM), docetaxel (IC50 = 8 nM) and vincristine (IC50 = 9 nM) measured from the primary screen. (d) Chemical structures of nocodazole, colchicine, docetaxel and vincristine.

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