Figure 5

Temporal dynamics of the cells to HGF/SF treatment.

(a) The time dependent Gab1 and the Grb2 signals that imitate the effect of HGF/SF treatment, as explained in the text. (b) Trajectory of the cell response projected on the phase diagram. The results are for a cell in which Gab1 activation of RhoA GTP loading is stronger than its activation of the Rac1 GTP loading (The parameters are gtp_R_hI₂ = 240h⁻¹ and gtp_R_cI₂ = 90h⁻¹ respectively). The solid line is the trajectory and both the arrows on the line and the color gradient of the line (from black to white) indicate the time evolution. The blue star marks the initial condition, the green star marks the peak of Gab1 expression and the pink star marks the peak of Grb2 expression. (c) Time dynamics of the expression levels of Rac1-GTP (Red) and RhoA-GTP (Black) in response to the signals, Gab1 and Grb2. The different phenotypes during the transition are highlighted by different background colors, where green, yellow and red areas stand for A, A/M and M phenotype respectively. (d) Similar to (b) but for a cell in which Gab1 activation of Rac1 loading is stronger than its activation of the RhoA loading (The parameters are gtp_R_cI₂ = 1000h⁻¹ and gtp_R_hI₂ = 240h⁻¹ respectively). (e) Similar to (c) but for the case shown in (d).