Figure 7
Phenotype distribution of a population of cells at different levels of Grb2 and Gab1 signals.
(a) Phenotype distribution of a population of cells driven by Grb2 signal (Gab1 = 0). The cell parameters are randomly distributed over ±5% relative to the original parameters. The y-axis denotes the percentage of cells corresponding to a specific phenotype. The color of each line represents a phenotype. Under the stimulation of different level of Grb2, a population of cells has different phenotype distribution (percentage of cells shown in y-axis). For each point, the original phase of the cells depends on the level of Grb2 signal. Note that due to the co-existence of different phenotypes in one phase (e.g. in both the phases {A, M, A/M} and {A, M}; A and M phenotypes are present), the sum of the total percentages for one particular signal level can be more than 100%. For example, the initial phase with neither Gab1 nor Grb2 signals is {A, A/M, M}. About 100% cells can be A or M phenotype and about 36% cells can be A/M. Some of these cells were in some multistable regime comprised of one or more of the phenotypes of A, M and A/M. (See Supplementary Fig. S8). (b) Phenotype distribution driven by Gab1 signal (Grb2 = 0). (c) Phenotype distribution under Grb2 and Gab1 regulations. The color of each bar, corresponding to the color definition above represents the initial cell phase. When both Grb2 and Gab1 signals are high, the cells are highly likely to be maintained in hybrid A/M phenotype.
