Figure 3 | Scientific Reports

Figure 3

From: Reduced miR-3127-5p expression promotes NSCLC proliferation/invasion and contributes to dasatinib sensitivity via the c-Abl/Ras/ERK pathway

Figure 3

miR-3127-5p knockdown promotes the tumorigenicity and metastasis in mouse xenograft model.

(A): Growth curve of subcutaneous tumors from A549 (upper panels) or H292 (bottom panels) cells transduced with Lv-3127, Lv-3127-off, or Lv-GFP in the first 5 weeks after inoculation. (B): Xenografted tumors were observed using a whole-body fluorescent imaging system at 30 days after inoculation. (C): After 13 weeks, animals were sacrificed and the number of visible neoplastic nodules (metastases) on each lung was counted. Representative photographs of the whole lungs and HE staining for lung metastasis lesion sections (100×) are shown. (D): Representative photographs of c-Abl, Ki-67, cyclin D1, MMP-9 and VEGF IHC of A549 or H292 xenograft tumors (200×).

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