Figure 1

Temporal Effects of Aggregate Formation on MDSCs.
(a) Aggregate formation markedly increased active caspase-3 expression (green) of MDSCs. (b) Aggregate formation significantly decreased MDSC phospho histone H3 (green) expression and proliferation. (c) Aggregate formation altered myocyte-specific gene expression patterns. * P < 0.05. ** P < 0.001 vs. baseline. Blue indicates nuclear DAPI staining. Scale bar indicates 20 μm.