Figure 5
From: Cancer-driven dynamics of immune cells in a microfluidic environment
Prospect of the perturbation of B16 cells in microfluidic devices loaded with WT or IRF8 KO immune cells.
(A) Perturbation factor has been calculated for three representative B16 cells (Mel1, Mel2, Mel3) taken in each device by depicting the area fraction of that cell in each timepoint respect to the preceding timepoint. This allowed to obtain the percentage area variation for each given timepoint for the 24–42 h time interval. The examined B16 cells were located in the melanoma compartment of the microfluidic devices. (B) Multiple comparison between B16 cells showed in panel A by Mann-Whitney U test. Each of three B16 cells from device loaded with WT immune cells (WT-Mel1, WT-Mel2, WT-Mel3) was combined with each of three B16 cells from device loaded with IRF8 KO immune cells (KO-Mel1, KO-Mel2, KO-Mel3).
