Table 2 Pathological grading of hepatic rejection
Portal Inflammation | 0 | None |
| Â | 1 | Mostly lymphocytic inflammation involving, but not noticeably expanding, a minority of the triads |
| Â | 2 | Expansion of most or all of the triads, by a mixed infiltrate containing lymphocytes with occasional blasts, neutrophils and eosinophils |
| Â | 3 | Marked expansion of most or all of the triads by a mixed infiltrate containing numerous blasts and eosinophils with inflammatory spillover into the periportal parenchyma |
Bile Duct Inflammation Damage | 0 | None |
| Â | 1 | A minority of the ducts are cuffed and infiltrated by inflammatory cells and show only mild reactive changes such as increased nuclear, cytoplasmic ratio of the epithelial cells |
| Â | 2 | Most or all of the ducts infiltrated by inflammatory cells. More than an occasional duct shows degenerative changes such as nuclear pleomorphism, disordered polarity and cytoplasmic vacuolization of the epithelium |
| Â | 3 | As above for 2, with most or all of the ducts showing degenerative changes or focal lumenal disruption |
Venous Endothelial Inflammation | 0 | None |
| Â | 1 | Subendothelial lymphocytic infiltration involving some, but not a majority of the portal and/or hepatic venules |
| Â | 2 | Subendothelial infiltration involving most or all of the portal and/or hepatic venules |
| Â | 3 | As above for 2, with moderate or severe perivenular inflammation that extends into the perivenular parenchyma and is associated with perivenular hepatocyte necrosis |
