Figure 2 | Scientific Reports

Figure 2

From: A Palindromic Motif in the −2084 to −2078 Upstream Region is Essential for ABCA12 Promoter Function in Cultured Human Keratinocytes

Figure 2

Annotation of the ABCA12 upstream gene using the ENCODE dataset.

The ABCA12 upstream genomic region (chr2:215,993,140–216,017,439:GRCh37/hg19) is illustrated using the UCSC genome browser. ChIP-seq signals and peaks of H3K4me3 and H3K27ac and DNAseI-seq peaks in NHEK were extracted from the ENCODE dataset and annotated. The read density of ChIP-seq signals is indicated in the Y-axis. ChIP-seq peaks of c-Fos/c-Jun in 91 human cell types from the ENCODE dataset are also shown. c-Fos peaks for MCF10A-Er-Src cells stimulated with tamoxifen for 4 hr (MCF10AEr + T4 FOS), 12 hr (MCF10AEr + T12 FOS), or 36 hr (MCF10AEr + T36 FOS) were found in the database search. The −2084/−2078 palindromic motif is boxed and its genetic location is highlighted with a dotted line. The predicted −2133/−2144 Sp1 binding element is also indicated.

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