Figure 4 | Scientific Reports

Figure 4

From: A Palindromic Motif in the −2084 to −2078 Upstream Region is Essential for ABCA12 Promoter Function in Cultured Human Keratinocytes

Figure 4

Mutants of the −2084/−2078 motif in ABCA12 show striking reduction of promoter activity.

Three different mutants of the −2084/−2078 motif were generated using the −2980/+190 fragment as a template and the promoter activity of each fragment was assessed. The mutants lacked 1–3 bases from the wild-type sequence (tgagtca): mutant Δ1 (tga-tca), mutant Δ2 (tga--ca) and mutant Δ3 (tg---ca). The promoter activities of the mutants were compared to that of the wild type. *P < 0.01 compared with the wild type.

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