Figure 6
From: Molecular evolution and functional divergence of tubulin superfamily in the fungal tree of life
Amino acid sites under Type II functional divergence in Fusarium Tub2 tubulins.
The names of Tub1 tubulins are in blue and those of Tub2 are in red. Residues identified in multiple sequence alignment to vary among Tub1 and Tub2 tubulins are highlighted in different colors. Red, blue and green arrows mark residues involved in GTP binding, α/β interface and β/α interface, respectively. “+” symbols mark sites that contribute to Type II functional divergence. Sites related to the tubulin function and/or structure were obtained according to the conserved domains of α-tubulin (cd02186) and β-tubulin (cd02187) in CDD of NCBI, respectively. Those boxed in red are amino acid sites reported to be associated with the fungal resistance to fungicide12,41,42. Abbreviations: Fg, Fusarium graminearum; Fv, F. verticillioides; Fo, F. oxysporum; Ff, F. fujikuroi; Fs, F. solani; Fp, F. pseudograminearum.
