Table 2 Meta-analysis of the association between BRCA2 polymorphism and cancer risk
Variables | No. of studiesa | Sample sizeb | Homozygous | Phetc | Heterozygous | Phetc | Dominant | Phetc | Recessive | Phetc |
|---|---|---|---|---|---|---|---|---|---|---|
All | 46 | 36299/48483 | 1.13 (1.03, 1.23) | <0.001 | 1.03 (0.99, 1.06) | 0.642 | 1.07 (1.01, 1.13) | <0.001 | 1.12 (1.02, 1.23) | <0.001 |
Cancer type | ||||||||||
Breast | 30 | 27121/33055 | 1.11 (0.99, 1.23) | <0.001 | 1.01 (0.97, 1.05) | 0.946 | 1.05 (0.98, 1.14) | <0.001 | 1.10 (0.98, 1.24) | <0.001 |
Ovarian | 4 | 2414/3717 | 1.13 (0.92, 1.38) | 0.587 | 1.14 (1.02, 1.27) | 0.154 | 1.13 (1.02, 1.26) | 0.384 | 1.06 (0.87, 1.30) | 0.334 |
NHL | 6 | 3893/5558 | 1.14 (0.83, 1.57) | 0.065 | 1.01 (0.90, 1.12) | 0.547 | 1.03 (0.92, 1.14) | 0.236 | 1.23 (1.01, 1.43) | 0.065 |
Others | 5 | 2762/5967 | 1.37 (1.08, 1.73) | 0.580 | 1.05 (0.95, 1.17) | 0.433 | 1.08 (0.96, 1.22) | 0.531 | 1.35 (1.07, 1.70) | 0.581 |
Ethnicity | ||||||||||
African | 2 | 991/754 | 2.24 (0.23, 21.77) | 0.026 | 1.06 (0.84, 1.33) | 0.816 | 1.36 (1.10, 1.69) | 0.440 | 2.19 (0.22, 21.72) | 0.025 |
Asian | 6 | 1113/1362 | 1.53 (0.99, 2.35) | 0.454 | 1.02 (0.81, 1.27) | 0.110 | 1.33 (0.81, 2.17) | <0.001 | 1.48 (0.85, 2.59) | 0.170 |
Caucasian | 34 | 30834/42264 | 1.07 (0.99, 1.16) | 0.133 | 1.02 (0.99, 1.06) | 0.605 | 1.03 (0.99, 1.07) | 0.255 | 1.08 (1.00, 1.16) | 0.038 |
Mixed | 4 | 3361/4103 | 1.15 (0.90, 1.48) | 0.141 | 1.06 (0.91, 1.23) | 0.888 | 1.06 (0.94, 1.20) | 0.681 | 1.33 (1.01, 1.75) | 0.660 |
Source of control | ||||||||||
HB | 11 | 4954/6532 | 0.98 (0.78, 1.24) | 0.204 | 0.94 (0.86, 1.04) | 0.419 | 0.96 (0.86, 1.07) | 0.271 | 1.07 (0.86, 1.33) | 0.063 |
PB | 27 | 26143/31462 | 1.18 (1.06, 1.32) | <0.001 | 1.04 (1.01, 1.08) | 0.746 | 1.11 (1.03, 1.19) | <0.001 | 1.14 (1.01, 1.29) | <0.001 |
Quality Score | ||||||||||
Low | 23 | 10991/19029 | 1.06 (0.94, 1.20) | 0.288 | 1.04 (0.98, 1.10) | 0.194 | 1.04 (0.98, 1.10) | 0.277 | 1.16 (1.06, 1.26) | 0.036 |
High | 23 | 25308/29454 | 1.17 (1.03, 1.32) | <0.001 | 1.02 (0.98, 1.06) | 0.917 | 1.06 (1.02, 1.10) | <0.001 | 1.09 (1.01, 1.17) | <0.001 |