Figure 4
From: A recurrent deletion mutation in OPA1 causes autosomal dominant optic atrophy in a Chinese family
Mitochondria morphology in skin fibroblasts.
The mitochondrion was labeled using the MitoTracker probe. MitoTracker (red) staining shows aberrant mitochondrial morphology and distribution in fibroblasts with the mutation. (A) Normal fibroblasts (Control) have spotty distribution of mitochondria. (B) Patient-derived fibroblasts have tubular distribution of mitochondria. Nuclei are labeled with DAPI. Scale bars = 20 μm in A, B. (C–D) The higher magnification view of A and B. (E) The different mitochondrial distribution in control and fibroblast of patient, respectively. (F) The average length of mitochondria in fibroblasts from the patient and control. HF-M represents the patient skin fibroblasts (HF-M, human skin fibroblasts with mutation).
