Figure 5
DMiroS182A,S324A,T325A or Loss of PINK1 Causes Synaptic Overgrowth and DA Neurodegeneration.
(A) NMJ boutons visualized by anti-HRP at muscle 4 hemisegment A2 of third instar larvae. (B) Quantification of the type Ib bouton number normalized to the muscle size at muscle 4 hemisegment A2 shown in (A), or at muscle 6/7 hemisegment A2. n = 11–16 larvae. (C) The PPL1 clusters of DA neurons visualized by anti-TH in adult brains 15 days after eclosion. (D) Quantification of the number of DA neurons in one PPL1 or PPL2 cluster per brain of adult flies of 15 days after eclosion shown in (C), or of 5 days after eclosion. n = 10–18 brains. Scale bars: (A) 50 μm; (C) 5 μm.
