Figure 2
From: PGRN protects against colitis progression in mice in an IL-10 and TNFR2 dependent manner
PGRN−/− mice are highly susceptible to DSS induction.
DSS colitis model was established in wild-type (n = 10) and PGRN−/− (n = 8) mice by administration of 3% DSS solution in drinking water for 5 days, followed by normal drinking water for 2 days. (A) Survival rate was monitored until day 13 after DSS induction. (B) Body weight. (C) Stool consistency. (D) Bleeding scores. (E) Mice were sacrificed on day 7 to measure colon length. (F) Histopathological changes. (G) Semiquantitative scoring of histopathology was performed as described in Methods. Scale bars, 200 μm.
