Figure 4
From: PGRN protects against colitis progression in mice in an IL-10 and TNFR2 dependent manner
PGRN signaling in hematopoietic cells is important for protection against DSS-induced colitis.
WT/WT (n = 6) and WT/PGRN−/− (n = 6) mice were fed a 3% DSS solution in drinking water for 5 days, followed by normal drinking water for 2 days. (A) Body weight, (B) Histopathological changes in colon tissue. (C) Semiquantitative scoring of histopathology. Scale bars, 200 μm.
