Figure 6
From: PGRN protects against colitis progression in mice in an IL-10 and TNFR2 dependent manner
Intestinal barrier function and the microbiota are not altered in PGRN−/− mice.
(A) Intestinal permeability was examined by detection of a FITC-dextran in the serum from DSS-induced mice. (B–E) Q-PCR analysis of intestinal microbiota in naïve or DSS-treated wild-type and PGRN−/− mice. Values are shown as a relative ratio to total bacterial 16 s rDNA measured by 2−ΔΔct method. All data represent means ± SE of three independent experiments. *p < 0.05; **p < 0.01.
