Figure 4
In vivo assessment of the efficiency of RF radiation-based hyperthermia using Si-based nanosensitizers.
(a) Schematics of the RF radiation-based therapy setup: (1) is a RF radiation source, (2) are the RF electrodes, (3) is a mouse having a tumor area. This Figure was created by the authors; (b) and (c) are histology images of a tumor area 1 h and 3 days after the PSi NP injection and RF-based treatment using PSi NPs as nanosensitizers, respectively. Cancer cells are visible as dark blue spots. Examples of agglomerations of PSi NPs in the cells are indicated by red arrows. (d) Inhibition of the tumor growth after the following treatments: the injection of Si NPs suspension without RF irradiation (black curve); 2 min treatment of tumor area by RF irradiation with the intensity of 2 W/cm2 (blue); injection of a suspension of PSi NPs (0.5 mL, 1 mg/mL) followed by 2 min RF irradiation treatment (red); injection of a suspension of LA-Si NPs (0.2 mL, 0.4 mg/mL) followed by 2 min RF irradiation treatment (green).
