Figure 3
Higher transcript abundance for rat lncRNA genes was often associated with increased H3K4me3 binding to promoter regions.
A. Chromatin fragments immunoprecipitated from five rat tissues using an antibody for histone H3K4me3 were enriched for a GAPDH promoter region, but not a myoglobin exon region. Promoter regions for lncRNAs with higher transcript abundance in the liver (B), cardiac left ventricle (C), renal cortex (D), or renal outer medulla (E) were enriched in chromatin fragments immunoprecipitated from the respective tissue using an antibody for histone H3K4me3. The promoter enrichment was minimal for an lncRNA with higher transcript abundance in the hypothalamus (F). The lncRNAs for which promoter data are shown in the current figure correspond to those for which transcript abundance data are shown in Figure 2. Li, liver; LV, cardiac left ventricle; C, renal cortex; M, renal outer medulla; H, hypothalamus; A, adrenal gland.
