Figure 2 | Scientific Reports

Figure 2

From: Global human frequencies of predicted nuclear pathogenic variants and the role played by protein hydrophobicity in pathogenicity potential

Figure 2

Assessing Selection as a Function of the Pathogenicity Score in nDNA and mtDNA Encoded Proteins.

(A) Probability distributions of all possible and observed amino acid variant pathogenicity scores in nDNA and mtDNA encoded proteins. (B) The selection function for the amino acid variants in nDNA and mtDNA encoded proteins, defined by dividing the observed distributions of pathogenicity scores by the distribution of scores for all possible variants.

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