Figure 3

LysM-Cre; Tak1^f/f mice showed osteopetrosis phenotype.

(a) Radiographic images of 2 month-old LysM-Cre; Tak1^f/f and control mice. (b–f). Trabecular bone parameters in 2 month-old LysM-Cre; Tak1^f/f and control mice. BV/TV (b). Tb area (c). Tb thickness (d). Tb number (e). Tb separation (f). The femurs were embedded with resin, sliced and stained with villauneva-goldner's one step trichrome method. All bone-specific parameters were measured and expressed in units following the guidelines established by the American Society for Bone and Mineral Research histomorphometry nomenclature committee using OsteoMeasure software (OsteoMetrics Inc). N = 8. *p < 0.05 when the value of mutant mice was compared to that of control mice.