Figure 3 | Scientific Reports

Figure 3

From: Integrating computational modeling and functional assays to decipher the structure-function relationship of influenza virus PB1 protein

Figure 3

The functional features of PB1.

(A) Local sequence and structural alignments between PB1 and RdRP templates. Norwalk Virus (NV-RdRP) and Dengue Virus (DV-RdRP) were colored with orange and gray separately. The “flap” insertion segment on DV relative to PB1 and NV was marked with rectangle. As the 2nd structure (2ND-STR) elements alignment, H means helix, C means coil. (B) The mapping of the 17 reported functional sites and 3 functional regions on the PB1 model. Reported 17 functional important sites (Supplementary Table 3), two nuclear localization signal (NLS) regions (187–195 and 203–216) and antigenic epitope (586–599) were colored red, purple and blue separately. Epitope was highlighted with surface mesh.

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