Table 1 Characteristics of studies included in the meta-analysis

From: Comparison of Hepatic Resection and Radiofrequency Ablation for Small Hepatocellular Carcinoma: A Meta-Analysis of 16,103 Patients

           

  Newcastle-Ottawa Scale

Study

Design

Period

Country

Therapy

No. pts.

Age (mean ± SD)

Sex (m/f)

Tumor size (mean ± SD, cm)

Tumor amount (single/multiple)

Child-Pugh class (A/B/C)

Total

Selection

Comparability

Outcome

Chen MS 20068

RCT

1999–2004

China

HR

90

49.4 ± 10.9

75/15

≤5 cm

90/0

90/0/0

9

4

2

3

    

RFA

71

51.9 ± 11.2

56/15

≤5 cm

71/0

71/0/0

    

Huang J 20106

RCT

2003–2005

China

HR

115

55.9 ± 12.7

85/30

≤5 cm

89/26

106/9/0

8

4

1

3

    

RFA

115

56.6 ± 14.3

79/36

≤5 cm

84/31

110/5/0

    

Feng K 20129

RCT

2005–2008

China

HR

84

47 (18–76)

75/9

2.6 ± 0.8

52/32

43/41/0

9

4

2

3

    

RFA

84

51 (24–83)

79/5

2.4 ± 0.6

48/36

39/45/0

    

Vivarelli M 200436

NRCT

1998–2002

Italy

HR

79

65.2 ± 8.2

57/22

-

66/13

70/9/0

6

3

0

3

    

RFA

79

67.8 ± 8.7

67/12

-

46/33

43/36/0

    

Hong SN 200514

NRCT

1999–2001

Korea

HR

93

49.2 ± 9.9

69/24

2.5 ± 0.8

93/0

-

6

3

0

3

    

RFA

55

59.1 ± 9.6

41/14

2.4 ± 0.6

55/0

-

    

Cho CM 200517

NRCT

2000–2002

Korea

HR

61

57

48/13

3.4 ± 1.0

-

61/0/0

7

3

1

3

    

RFA

99

58

76/23

3.1 ± 0.8

-

99/0/0

    

Montorsi M 200516

NRCT

1997–2003

Italy

HR

40

67 ± 9

33/7

≤5 cm

40/0

32/8/0

7

3

1

3

    

RFA

58

67 ± 6

43/15

≤5 cm

58/0

40/18/0

    

Gao W 200718

NRCT

1999-2006

China

HR

34

51.5 (38–67)

28/6

2.6 ± 0.4

32/2

33/1/0

6

3

0

3

    

RFA

53

57.1 (31–81)

41/12

2.5 ± 0.4

29/24

40/11/2

    

Lupo L 200715

NRCT

1999–2006

Italy

HR

42

67 (28–80)

33/9

4.0 (3.0–5.0)

42/0

28/14/0

8

3

2

3

    

RFA

60

68 (42–85)

47/13

3.7 (3.0–5.0)

60/0

44/16/0

    

Zhou T 200719

NRCT

2001–2006

China

HR

40

53 ± 13

35/5

≤5 cm

38/2

37/3/0

8

3

2

3

    

RFA

47

57 ± 14

37/10

≤5 cm

40/7

40/7/0

    

Abu-Hilal M 200820

NRCT

1991–2003

UK

HR

34

67

26/8

3.8

34/0

25/9/0

7

3

1

3

    

RFA

34

65

27/7

3.0

34/0

27/7/0

    

Hiraoka A 200833

NRCT

2000–2007

Japan

HR

59

62.4 ± 10.6

44:15

2.27 ± 0.55

59/0

54/5/0

7

3

1

3

    

RFA

105

69.4 ± 9.1

76:29

1.98 ± 0.52

105/0

79/26/0

    

Guglielmi A 200821

NRCT

1996–2006

Italy

HR

91

-

73/18

≤6 cm

69/21

69/22/0

6

3

0

3

    

RFA

109

-

88/21

≤6 cm

65/44

64/45/0

    

Bu XY 200938

NRCT

2000–2006

China

HR

42

53.9 ± 10.7

36/6

≤5 cm

38/4

36/6/0

7

3

1

3

    

RFA

46

55.9 ± 7.4

40/6

≤5 cm

38/8

25/21/0

    

Santambrogio R 200922

NRCT

1997–2007

Italy

HR

78

68 ± 8

55/23

2.91 ± 1.23

78/0

78/0/0

8

3

2

3

    

RFA

74

68 ± 7

59/15

2.66 ± 1.06

74/0

74/0/0

    

Ueno S 200935

NRCT

2000–2005

Japan

HR

123

67 (28–85)

82/41

2.7 ± 0.1

110/13

91/31/1

6

3

0

3

    

RFA

155

66 (40–79)

100/55

2.0 ± 0.1

101/54

52/92/11

    

Guo WX 201031

NRCT

2002–2007

China

HR

73

50.5 (17–68)

57/16

3.5

0/73

71/2/0

7

3

1

3

    

RFA

86

52.5 (26–80)

63/23

3.2

0/86

84/2/0

    

Yun WK 20107

NRCT

2000–2007

Korea

HR

215

51.7 ± 9.7

171/44

2.1 ± 0.5

215/0

215/0/0

6

3

0

3

    

RFA

255

57.0 ± 9.9

197/58

2.1 ± 0.5

255/0

255/0/0

    

Hung HH 201113

NRCT

2002–2007

China

HR

229

60.1 ± 12.6

184/45

2.88 ± 1.06

181/48

-

6

3

0

3

    

RFA

190

67.4 ± 11.5

121/69

2.37 ± 0.92

152/38

-

    

Liu H 201123

NRCT

2008–2010

China

HR

35

48.2 ± 15.6

29/6

≤5 cm

35/0

35/0/0

7

3

1

3

    

RFA

32

46.1 ± 24.1

26/6

≤5 cm

32/0

32/0/0

    

Nishikawa H 201110

NRCT

2004–2010

Japan

HR

69

67.4 ± 9.7

50/19

2.68 ± 0.49

69/0

45/5/0

7

3

1

3

    

RFA

162

68.4 ± 8.7

95/67

1.99 ± 0.62

162/0

102/22/3

    

Wang JH 201126

NRCT

2002–2009

China

HR

260

-

206/54

≤3 cm

241/19

257/3/0

7

3

1

3

    

RFA

345

-

221/124

≤3 cm

264/81

282/63/0

    

Zhang J 201137

NRCT

2006–2009

China

HR

103

56.4 ± 15.2

78/25

≤5 cm

89/14

81/22/0

6

3

0

3

    

RFA

85

58.5 ± 12.9

62/23

≤5 cm

59/16

31/39/15

    

Du JK 201224

NRCT

2003–2007

China

HR

58

56.6 ± 8.6

33/25

≤5 cm

-

-

6

3

0

3

    

RFA

58

58.3 ± 8.2

36/22

≤5 cm

-

-

    

Imai K 201234

NRCT

2000–2011

Japan

HR

101

63.3 ± 1 9.7

75/26

2.14 ± 0.55

101/0

97/4/0

6

3

0

3

    

RFA

82

67.6 ± 1 8.5

46/36

1.87 ± 0.50

82/0

60/22/0

    

Peng ZW 201225

NRCT

2003–2008

China

HR

74

51.5 ± 12.1

65/9

1.1 ± 0.5

74/0

62/0/12

8

3

2

3

    

RFA

71

51.1 ± 12.1

63/8

1.2 ± 0.6

71/0

58/0/13

    

Tohme S 201229

NRCT

2001–2011

USA

HR

50

66.3 ± 1

31/19

3.07 ± 1.17

39/11

27/6/17

6

2

1

3

    

RFA

60

65.6 ± 12

38/22

2.36 ± 1.94

47/13

40/16/4

    

Desiderio J 201327

NRCT

2004–2012

Italy

HR

52

65.6 ± 4.8

37/15

≤3 cm

22/30

52/0/0

7

3

1

3

    

RFA

44

64.4 ± 6.5

35/9

≤3 cm

19/25

44/0/0

    

Hasegawa K 201332

NRCT

2000–2005

Japan

HR

5361

66 (48–77)

3967/1394

≤3 cm

4458/903

4000/1361/0

6

3

0

3

    

RFA

5548

69 (52–80)

3569/1979

≤3 cm

4068/1480

3349/2199/0

    

Lai EC 201328

NRCT

2006–2012

China

HR

80

60.8 ± 9.9

55/25

2.9 ± 1.1

71/9

-

7

3

1

3

    

RFA

31

63.1 ± 12.8

19/12

1.8 ± 0.6

28/3

-

    

Wong KM 201330

NRCT

2004–2009

China

HR

46

55.1 ± 12

30/16

2.1 ± 0.6

46/0

46/0/0

7

3

1

3

    

RFA

36

63.5 ± 13

18/18

1.9 ± 0.6

36/0

36/0/0

    
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