Figure 3
A model for the dual roles of MDF1 in the mating and growth pathways.
Promotion of vegetative growth can be achieved through two converging pathways: Mdf1p binds to the MATĪ±2 protein to cooperatively inhibit haploid-specific genes that encode key components of the mating pathway (MAPK pathway) and thereby suppresses the mating behavior of budding yeast to limit the cost of mating, as revealed in a previous study by our group; and Mdf1p binds to Snf1p to turn off glucose-repressed genes and turn on glucose-induced genes, thus enhancing the activity of the glucose signaling pathway.
