Figure 8
From: RILP interacts with HOPS complex via VPS41 subunit to regulate endocytic trafficking
A working model of HOPS-Rab7-RILP interaction on the endosomal membrane.
In this model, Rab7 interacts with both accessory subunits VPS39 and VPS41 of HOPS complex, while RILP interacts with Rab7 and VPS41 to stabilze Rab7-HOPS at the endosomal membrane. (B). a working model of Rab7 modulating endosomal membrane transition regulated by Mon1/Ccz1, HOPS and RILP. In this model, Mon1-Ccz1 plays cis-regulation to exclude Rab5 and recruit HOPS complex, activating Rab7, while RILP plays trans-regulation to stabilize Rab7-HOPS complex onto late endosomal membrane.
