Figure 1
From: Crystal structure of Escherichia coli YidC, a membrane protein chaperone and insertase
Structure of EcYidC.
(A), Ribbon representations of the EcYidC structure, viewed transversely through the membrane. (B), Close-up view of the hydrophobic core of EcYidC and the interaction surface between the P1 domain and the TM region (stereo view). Hydrogen bonds are shown as dashed lines. (C), Surface model representations of EcYidC, sliced through the center of the groove. The structure is colored according to the electrostatic potential, ranging from blue (+10 kT/e) to red (−10 kT/e). (D), Close-up view of the hydrophilic groove of EcYidC (colored), showing hydrophilic residues. BhYidC (grey) is superimposed on the TM region of EcYidC. The side chain of Arg72 in BhYidC (corresponding to Arg366 in EcYidC) is shown. (E), Surface model representations of EcYidC colored according to sequence conservation, ranging from cyan (low) to maroon (high). Dotted regions highlight the conserved surfaces in the P1-TM interface (yellow) and the TM3 helix (light green).
