Table 2 The detailed characteristics of all eligible studies for MTHFR A1298C polymorphism
MTHFR A1298C | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Children | Mother | |||||||||||||||||
Cases | Controls | Cases | Controls | |||||||||||||||
Study | Year | Country (Ethnicity **) | AA | AC | CC | AA | AC | CC | HWE | AA | AC | CC | AA | AC | CC | HWE | Methods | Main types of CHD * |
Storti et al | 2003 | Italy (C) | 45 | 47 | 11 | 101 | 86 | 13 | 0.387 | 49 | 46 | 8 | 101 | 86 | 13 | 0.387 | PCR-RFLP | VSD,TOF, DORV, PA, d-TGA, AC |
Nurk et al | 2004 | Norway (C) | — | — | — | — | — | — | — | 9 | 13 | 3 | 6607 | 6342 | 1525 | 0.955 | RT-PCR | Congenital Anomalies Heart |
Galdieri et al | 2007 | Brazil (M) | 35 | 21 | 1 | 19 | 16 | 3 | 1.000 | 26 | 17 | 4 | 15 | 10 | 1 | 1.000 | PCR-RFLP | Congenital Heart Defects |
van Driel et al | 2008 | Netherlands (C) | 112 | 90 | 27 | 97 | 129 | 25 | 0.073 | 104 | 102 | 24 | 116 | 104 | 31 | 0.319 | PCR-RFLP | TOF, TGA, ASD, VSD, CoA, AS, PS, HLHS, |
Obermann-Borst et al | 2010 | Netherlands (C) | 69 | 57 | 13 | 75 | 90 | 18 | 0.256 | — | — | — | — | — | — | — | PCR-RFLP | TOF, TGA, ASD, VSD, CoA, AS, PS, HLHS |
Xu et al | 2010 | China (A) | 316 | 168 | 18 | 326 | 185 | 16 | 0.110 | — | — | — | — | — | — | — | PCR-RFLP | Cyanotic Cardiac Disease, ASD, VSD, PDA, Left-sided Obstruction Defects. |
Weiner et al | 2012 | Russia (C) | — | — | — | — | — | — | — | 33 | 13 | 2 | 168 | 152 | 42 | 0.403 | RT-PCR | Congenital Anomalies-cardiovascular System |
Wang et al | 2013 | China (A) | 115 | 45 | 10 | 133 | 47 | 8 | 0.186 | — | — | — | — | — | — | — | SEQUENCE | Congenital Heart Disease |
Sahiner et al | 2013 | Turkey (C) | 45 | 68 | 24 | 31 | 54 | 8 | 0.029 | — | — | — | — | — | — | — | PCR-RFLP | Obstruction in LV Output, Left-to-right Shunt, Conotruncal Anomalies, Complex Anomalies |
Zidan et al | 2013 | Egypt (AR) | 16 | 27 | 37 | 26 | 24 | 27 | 0.001 | 13 | 32 | 25 | 33 | 25 | 22 | 0.001 | PCR-RFLP | ASD, VSD, PDA, PS, TOF, HLHS, Combined lesion |
Christensen et al *** | 2013 | USA (C) | 78 | 67 | 12 | 38 | 26 | 5 | 0.764 | 98 | 71 | 13 | 36 | 22 | 7 | 0.220 | PCR-RFLP | VSD, TOF, AS, TGA, AVSD, DORV, PS, CoA, Truncus Arteriosus |
Huang et al | 2014 | China (A) | 111 | 56 | 3 | 146 | 56 | 6 | 0.800 | — | — | — | — | — | — | — | MS | TOF |
