Table 4 Main results of association between MTHFR A1298C polymorphism and CHD

		Sample size		Test of heterogeneity			Test of association				Test of publication bias
Subgroup	Genetic model	Patients	Controls	Q	P	I² (%)	OR	95% CI	Z	P	z	P
Children Overall	C VS. A	1,834	1,744	14.21	0.077	43.7	1.044	0.890–1.225	0.53	0.595	0.31	0.754
	CC vs. AA			9.05	0.338	11.6	1.260	0.950–1.671	1.60	0.109	0.10	0.917
	CC vs. AC			4.56	0.804	0.00	1.354	1.022–1.793	2.11	0.034	1.56	0.118
	Dominant model			14.34	0.073	44.2	0.978	0.792–1.206	0.21	0.832	0.36	0.175
	Recessive model			5.83	0.666	0.0	1.322	1.015–1.732	2.07	0.038	0.52	0.602
Maternal Overall	C VS. A	705	15,458	16.60	0.011	63.9	1.041	0.781–1.386	0.27	0.785	0.60	0.548
	CC vs. AA			11.15	0.084	46.2	1.085	0.631–1.864	0.29	0.769	0.00	1.000
	CC vs.AC			2.07	0.913	0.0	0.841	0.587–1.205	0.94	0.346	0.60	0.548
	Dominant model			17.61	0.007	65.9	1.107	0.748–1.639	0.51	0.612	0.60	0.548
	Recessive model			5.39	0.495	0.00	0.966	0.690–1.352	0.20	0.839	0.30	0.764
Caucasian Children	C VS. A	765	796	6.76	0.149	40.8	0.989	0.848–1.154	0.14	0.891	–	–
	CC vs. AA			4.15	0.386	3.60	1.177	0.819–1.691	0.88	0.378	–	–
	CC vs. AC			2.22	0.695	0.00	1.484	1.035–2.128	2.15	0.032	–	–
	Dominant model			7.83	0.098	48.9	0.916	0.681–1.231	0.58	0.559	–	–
	Recessive model			2.92	0.571	0.00	1.332	0.944–1.878	1.63	0.103	–	–
Caucasian Maternal	C VS. A	588	15,352	9.17	0.057	56.4	0.920	0.693–1.223	0.57	0.567	–	–
	CC vs. AA			4.43	0.364	7.4	0.850	0.565–1.278	0.78	0.434	–	–
	CC vs. AC			1.25	0.870	0.00	0.802	0.531–1.212	1.05	0.295	–	–
	Dominant model			9.22	0.056	56.6	0.943	0.652–1.363	0.31	0.753	–	–
	Recessive model			2.77	0.597	0.00	0.824	0.557–1.217	0.97	0.330	–	–

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