Table 5 Sensitivity analysis of association between MTHFR C677T polymorphism and CHD

From: Association Between MTHFR Polymorphisms and Congenital Heart Disease: A Meta-analysis based on 9,329 cases and 15,076 controls

  

  Test of heterogeneity

  Test of association

Subgroup

Genetic model

Q

P

I2 (%)

OR

95% CI

Z

P

Children Overall

TT vs. CT

32.42

0.020

44.5

1.303

1.064–1.596

2.56

0.010

 

Recessive model

61.61

0.000

70.8

1.335

1.028–1.735

2.16

0.030

Maternal Overall

T vs. C

32.48

0.006

53.8

1.215

1.042–1.425

2.48

0.013

 

TT vs. CC

29.99

0.012

50.0

1.570

1.125–2.192

2.65

0.008

 

TT vs. CT

26.09

0.037

42.5

1.462

1.104–1.937

2.65

0.008

 

Dominant model

22.10

0.105

32.1

1.198

1.035–1.386

2.43

0.015

 

Recessive model

29.49

0.014

49.1

1.527

1.149–2.030

2.92

0.004

Asian Maternal

T vs. C

3.96

0.412

0.0

1.595

1.348–1.886

5.45

5.04e-8

 

TT vs. CC

3.49

0.479

0.0

2.548

1.788–3.631

5.18

2.22e-7

 

TT vs. CT

1.51

0.825

0.0

1.884

1.415–2.509

4.34

1.42e-5

 

Dominant model

4.93

0.295

18.9

1.605

1.215–2.121

3.33

0.001

 

Recessive model

2.05

0.727

0.0

2.073

1.583–2.716

5.29

1.22e-7

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