Table 1 Comparative genomics analysis of three respiratory pathogens from recent China outbreaks: HAdV-7d strains DG01_2011, 0901HZ/ShX/2009 and CQ1198_2010. Nucleic acid and amino acid sequence changes are noted, along with their genome locations and coding consequences. The reference genome is 0901HZ/ShX/2009. *ITR: inverted terminal repeat. “-“: no change or not applicable
Nucleotide change | Amino acid substitution (DG01_2011/CQ1198_2010) | |||||
|---|---|---|---|---|---|---|
Region | Position | Gene | DG01_2011 | CQ1198_2010 | Non-synonymous | Synonymous |
ITR* | 1-6 | - | - | Deletion of CATCAT | -/- | -/- |
ITR | 58 | - | T→C | - | -/- | -/- |
Non-coding Region | 518 | - | Insertion of T | - | -/- | -/- |
E2B | 5517 | DNA polymerase | G→C | - | D→E/- | -/- |
8470 | - | G→C | -/S→C | -/- | ||
L1 | 10830 | Virus-Associated RNA II | G→A | - | -/- | -/- |
L2 | 14594 | Penton base | T→C | - | V→A/- | -/- |
L4 | 24298 | Hexon assembly -associated protein | C→T | C→T | -/- | A→A/A→A |
E4 | 33155 | 34 kDa protein | G→T | G→T | P→Q/P→Q | -/- |
ITR | 35182 | - | A→G | - | -/- | -/- |
ITR | 35239 | - | - | Deletion of G | -/- | -/- |
