Figure 3
From: Functional Role of Calstabin2 in Age-related Cardiac Alterations
Calstabin2-null mice exhibit increased cellular senescence.
(A), Cardiac sections were analyzed for SA β-gal staining (arrows). The deletion of Calstabin2 leads to significant increase in SA β-gal activity in both young and aged mice. Scale bar = 10 μm. (B), Quantification of SA β-gal positive cells in young and aged mice. (C), mRNA transcript levels of the cell cycle inhibitors p16, p19, p21 and p53, as determined by real-time RT-qPCR. p16 and p19 were significantly increased in aged KO mice. n = at least 5 per group; *p < 0.05, **p < 0.01 and ***p < 0.001.
