Figure 4

Effect of genotype and treatment on systolic blood pressure and heart rate depending on gender.
Systolic blood pressure (a, c) and heart rate (b,d) was measured in 5–7month-old animals for 5 consecutive days (0 d) using external tail pulse detection. After this time period aldosterone releasing pellets were implanted subcutaneously in the back of the animals. After a three day recovery period blood pressure and heart rate were measured twice weekly for additional 28 days. Data are given as mean ± SEM, * p<0.05 compared to respective wildtype, # p<0.05 compared to respective control. N = 9–12 animals/group.