Figure 3
Bilirubin enhances and inhibits nAChR currents in rat SCG neurons in a dose-dependent manner.
(A) Representative traces of nAChR currents enhanced and inhibited by different concentrations of bilirubin (0.5, 2, 3, 4 and 5 μM). nAChR currents were activated by 100 μM ACh and the duration of fast perfusion ACh by gravity was about 8 s. (B) The dose-response relationship for bilirubin on ACh-induced peak currents. The response rates of ACh-induced currents by bilirubin were normalized to the control response induced by 100 μM ACh. (C) The dose-response relationship for bilirubin on desensitization of nAChRs. Desensitization of nAChRs by bilirubin was normalized to the control response induced by 100 μM ACh. Each data point is expressed as means ± SEMs (n = 5).
