Figure 8
Bilirubin is involved in the cAMP and PKA pathway in suppressing nAChR currents.
The inhibitory effect of bilirubin on nAChR currents persisted in the presence of 10 μM forskolin. (A) Representative traces of nAChR currents inhibited by 4 μM bilirubin persisted in the presence of 10 μM forskolin. (B) The dose-response relationship for bilirubin on ACh-induced peak currents persisted in the presence of 10 μM forskolin. The response rates of ACh-induced currents by bilirubin were normalized to the control response induced by 100 μM ACh. (C) The dose-response relationship for bilirubin on desensitization of nAChR persisted in the presence of 10 μM forskolin. Desensitization of nAChRs by bilirubin was normalized to the control response induced by 100 μM ACh. Each data point is expressed as means ± SEMs (n = 5).
